Article
The association between the polymorphisms in a sodium channel gene SCN7A and essential hypertension: a case-control study in the Northern Han Chinese.
Annals of human genetics - 1 Jan 2015
Zhang Bei, Li Mei, Wang Lijuan, Li Chuang, Lou Yuqing, Liu Jielin, Liu Ya, Wang Zuoguang, Wen Shaojun
Abstract excerpt
Nax , an α-subunit of the sodium channel encoded by the SCN7A gene, has been deemed to be a sensor of the concentration of sodium in the brain and may be involved in salt intake behavior. We inferred that Nax /SCN7A may participate in the regulation of blood pressure and the pathogenesis of essential hypertension (EH). The present case-control study involving 615 hypertensives and 617 normotensives was performed...
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