Article
Association of genetic polymorphisms of sodium-calcium exchanger 1 gene, NCX1, with hypertension in a Japanese general population.
Hypertension research : official journal of the Japanese Society of Hypertension - 1 Oct 2004
Kokubo Yoshihiro, Inamoto Nozomu, Tomoike Hitonobu, Kamide Kei, Takiuchi Shin, Kawano Yuhei, Tanaka Chihiro, Katanosaka Yuki, Wakabayashi Shigeo, Shigekawa Munekazu, Hishikawa Otosaburo, Miyata Toshiyuki
Abstract excerpt
The Na+/Ca2+ exchanger (NCX) is a membrane protein involved in calcium homeostasis, catalyzing the exchange of one Ca2+ ion for three Na+ ions across the cell membrane. The Na+/Ca2+ exchange has been suggested to play a role in the pathogenesis of hypertension. Therefore, we examined whether genetic variations in NCX1 were associated with hypertension. Among 15 polymorphisms identified in 96 hypertensive subjects...
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