Article
Association of SLC6A9 gene variants with human essential hypertension.
Journal of atherosclerosis and thrombosis - 1 Jun 2009
Ueno Takahiro, Tabara Yasuharu, Fukuda Noboru, Tahira Kazunobu, Matsumoto Taro, Kosuge Kotoko, Haketa Akira, Matsumoto Koichi, Sato Yuichi, Nakayama Tomohiro, Katsuya Tomohiro, Ogihara Toshio, Makita Yoshio, Hata Akira, Yamada Michiko, Takahashi Norio, Hirawa Nobuhito, Umemura Satosh, Miki Tetsuro, Soma Masayoshi
Abstract excerpt
AIM: We previously identified a quantitative trait locus (QTL) on rat chromosome 5 that appeared to be primarily controlled by the sympathetic nervous system. Because sympathetic overactivity is related to hypertension, solute carrier family 6, member 9 (SLC6A9) is a candidate gene for the connection of this QTL with blood pressure regulation. In the present study, we therefore explored the role of SLC6A9 genetic...
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