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Article

LAMA2 Neuropathies: Human Findings and Pathomechanisms From Mouse Models

23 Apr 2020

Abstract excerpt

gene, encoding for the alpha-2 chain of laminin-211. The disease is predominantly characterized by progressive muscular dystrophy affecting patient motor function and reducing life expectancy. However, LAMA2-RD also comprises a developmentally-associated dysmyelinating neuropathy that contributes to the disease progression, in addition to brain abnormalities; the latter often underappreciated. In this brief...

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PMID: 32390798
DOI: 10.3389/fnmol.2020.00060

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