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Article

Viral evolution during primary infection in immunocompromised hosts.

PLoS computational biology - 1 Feb 2026

Craig Morgan, Deng Xiaoyan, McLeod David V

Abstract excerpt

The immune response to viral infection is a delicate balance. By perturbing this balance, immunodeficiencies are expected to influence within-host viral evolution. Indeed, the presence of immunocompromised hosts has been argued to be a source of novel viral variants in some infectious diseases, including SARS-CoV-2. However, these arguments rest upon between-host models and so the role of immunodeficiencies on...

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Identifiers

PMID: 41739834
DOI: 10.1371/journal.pcbi.1013967
PMCID: PMC12935273

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