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Article

Experimental manipulation of population-level MHC diversity controls pathogen virulence evolution in Mus musculus.

Journal of evolutionary biology - 1 Feb 2018

Cornwall D H, Kubinak J L, Zachary E, Stark D L, Seipel D, Potts W K

Abstract excerpt

The virulence levels attained by serial passage of pathogens through similar host genotypes are much higher than observed in natural systems; however, it is unknown what keeps natural virulence levels below these empirically demonstrated maximum levels. One hypothesis suggests that host diversity impedes pathogen virulence, because adaptation to one host genotype carries trade-offs in the ability to replicate and...

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PMID: 29266576
DOI: 10.1111/jeb.13225

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