Characterization of alpha-toxin hla gene variants, alpha-toxin expression levels, and levels of antibody to alpha-toxin in hemodialysis and postsurgical patients with Staphylococcus aureus bacteremia.

doi:10.1128/JCM.02023-14

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Article

Characterization of alpha-toxin hla gene variants, alpha-toxin expression levels, and levels of antibody to alpha-toxin in hemodialysis and postsurgical patients with Staphylococcus aureus bacteremia.

Journal of clinical microbiology - 1 Jan 2015

Sharma-Kuinkel Batu K, Wu Yuling, Tabor David E, Mok Hoyin, Sellman Bret R, Jenkins Amy, Yu Li, Jafri Hasan S, Rude Thomas H, Ruffin Felicia, Schell Wiley A, Park Lawrence P, Yan Qin, Thaden Joshua T, Messina Julia A, Fowler Vance G, Esser Mark T

Abstract excerpt

Alpha-toxin is a major Staphylococcus aureus virulence factor. This study evaluated potential relationships between in vitro alpha-toxin expression of S. aureus bloodstream isolates, anti-alpha-toxin antibody in serum of patients with S. aureus bacteremia (SAB), and clinical outcomes in 100 hemodialysis and 100 postsurgical SAB patients. Isolates underwent spa typing and hla sequencing. Serum anti-alpha-toxin IgG...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25392350
DOI: 10.1128/JCM.02023-14
PMCID: PMC4290928

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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