Article

Highly sensitive detection of Staphylococcus aureus α-Hemolysin protein (Hla or α-toxin) by Apta-qPCR

2024-04-08

Abstract excerpt

α-toxin of Staphylococcus aureus is belonging to pore-forming toxins (PFTs) which can lyse red and white blood cells except neutrophils. In addition to existence of the hla gene in the majority of S. aureus strains (about 95%), higher expression exert enhanced pathogenicity to the bacteria. Various methods such as aptamer-based ones could serve for detection of the toxin. In the current study, an apta-qPCR assay i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f09f3493-b65e-5f68-a6b7-4f3245424c4f
DOI: 10.21203/rs.3.rs-4204970/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Highly sensitive detection of Staphylococcus aureus α-Hemolysin protein (Hla or α-toxin) by Apta-qPCRDOI 10.21203/rs.3.rs-4204970/v1Read

Staphylococcus aureus in vitro secretion of alpha toxin (hla) correlates with the affiliation to clonal complexes.Semantic proximity Read

Molecular detection of Alpha toxin in local Staphylococcus aureus isolatesSemantic proximity Read

Characterization of alpha-toxin hla gene variants, alpha-toxin expression levels, and levels of antibody to alpha-toxin in hemodialysis and postsurgical patients with Staphylococcus aureus bacteremia.Semantic proximity Read

Toxic Shock Syndrome Toxin-1 (TSST-1) in Staphylococcus aureus: Prevalence, Molecular Mechanisms, and Public Health ImplicationsSemantic proximity Read

Aptamers against Pathogenic Bacteria: Selection Strategies and Apta-assay/Aptasensor Application for Food SafetySemantic proximity Read

Staphylococcal enterotoxins: Molecular aspects and detection methodsSemantic proximity Read

The staphylococcal enterotoxin (SE) familySemantic proximity Read

Staphylococcus aureus α-Toxin: Nearly a Century of IntrigueSemantic proximity Read

Innovations in aptamer-based biosensors for detection of pathogenic bacteria: Recent advances and perspectiveSemantic proximity Read

Identification of a novel fully human anti-toxic shock syndrome toxin (TSST)-1 single-chain variable fragment antibody averting TSST-1-induced mitogenesis and cytokine secretionSemantic proximity Read

Toxic Shock Syndrome and Bacterial Superantigens: An UpdateSemantic proximity Read

Staphylococcus aureus Alpha-Toxin Is Conserved among Diverse Hospital Respiratory Isolates Collected from a Global Surveillance Study and Is Neutralized by Monoclonal Antibody MEDI4893.Semantic proximity Read