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Toxin exposure and HLA alleles determine serum antibody binding to toxic shock syndrome toxin 1 (TSST-1) of Staphylococcus aureus.

Frontiers in immunology - 1 Jan 2023

Weiss Stefan, Holtfreter Silva, Meyer Tanja C, Schmiedeke Frieder, Cammann Clemens, Dörr Marcus, Felix Stephan B, Grabe Hans J, Homuth Georg, Kohler Christian, Mahncke Cedric, Michalik Stephan, Nauck Matthias, Friedrich Nele, Samietz Stefanie, Völzke Henry, Völker Uwe, Bröker Barbara M

Abstract excerpt

Life-threatening toxic shock syndrome is often caused by the superantigen toxic shock syndrome toxin-1 (TSST-1) produced by Staphylococcus aureus. A well-known risk factor is the lack of neutralizing antibodies. To identify determinants of the anti-TSST-1 antibody response, we examined 976 participants of the German population-based epidemiological Study of Health in Pomerania (SHIP-TREND-0). We measured...

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Identifiers

PMID: 37731490
DOI: 10.3389/fimmu.2023.1229562
PMCID: PMC10507260

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