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β-Hemolysin, not agrA mutation, inhibits the hemolysis of α-hemolysin in Staphylococcus aureus laboratory and clinical strains.

mSphere - 28 Feb 2024

Liu Lin, Zhuang Hemu, Wang Yanfei, Tu Yuexing, Yu Yunsong, Chen Yan, Wu Xueqing

Abstract excerpt

Staphylococcus aureus produces various hemolysins regulated by the Agr-QS system, except β-hemolysin encoded by the gene hlb. A classical laboratory S. aureus strain RN4220 displays only the β-hemolysin phenotype. It was suspected that the 8A mutation at the end of its agrA gene delayed the expressions of hla and RNAIII, then failed to express α- and δ-hemolysins. However, hla gene expression was detected at the...

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Identifiers

PMID: 38289073
DOI: 10.1128/msphere.00673-23
PMCID: PMC10900901

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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