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Article

The TWEAK Receptor Fn14 Is an Src-Inducible Protein and a Positive Regulator of Src-Driven Cell Invasion.

Molecular cancer research : MCR - 1 Mar 2015

Cheng Emily, Whitsett Timothy G, Tran Nhan L, Winkles Jeffrey A

Abstract excerpt

The TNF receptor superfamily member Fn14 (TNFRSF12A) is the sole signaling receptor for the proinflammatory cytokine TWEAK (TNFSF12). TWEAK: Fn14 engagement stimulates multiple signal transduction pathways, including the NF-κB pathway, and this triggers important cellular processes (e.g., growth, differentiation, migration, and invasion). The TWEAK-Fn14 axis is thought to be a major physiologic mediator of tissue...

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Source

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Identifiers

PMID: 25392346
DOI: 10.1158/1541-7786.MCR-14-0411
PMCID: PMC4369191

Genes

EGFR
TNF
TNFSF12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The TWEAK Receptor Fn14 Is an Src-Inducible Protein and a Positive Regulator of Src-Driven Cell Invasion.PMID 25392346Read ↗

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