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Article

TWEAK binding to the Fn14 cysteine-rich domain depends on charged residues located in both the A1 and D2 modules.

The Biochemical journal - 15 Jul 2006

Brown Sharron A N, Hanscom Heather N, Vu Hong, Brew Shelesa A, Winkles Jeffrey A

Abstract excerpt

TWEAK [TNF (tumour necrosis factor)-like weak inducer of apoptosis] is a member of the TNF superfamily of cytokines. TWEAK binds with high affinity to a single TNF receptor super-family member, Fn14 (fibroblast growth factor-inducible 14). This interaction can stimulate a variety of biological responses, depending on the cell type analysed. The murine Fn14 extracellular region is only 53 amino acids in length and...

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Source

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Identifiers

PMID: 16526941
DOI: 10.1042/BJ20051362
PMCID: PMC1513280

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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