Article
A new risk variant for multiple sclerosis at the immunoglobulin heavy chain locus associates with intrathecal IgG, IgM index and oligoclonal bands.
Multiple sclerosis (Houndmills, Basingstoke, England) - 1 Aug 2015
Delgado-García Mercedes, Matesanz Fuencisla, Alcina Antonio, Fedetz María, García-Sánchez María Isabel, Ruiz-Peña Juan Luis, Fernández Óscar, Pinto Medel María Jesús, Leyva Laura, Arnal Carmen, Delgado Concepción, López Guerrero José Antonio, González-Pérez Antonio, Sáez María E, Villar Luisa María, Álvarez-Cermeño José Carlos, Picón Carmen, Arroyo Rafael, Varadé Jezabel, Urcelay Elena, Izquierdo Guillermo, Lucas Miguel
Abstract excerpt
BACKGROUND: Recent findings have shown a correlation between the intrathecal IgG index and variants at the immunoglobulin heavy chain (IGHC) locus in patients with multiple sclerosis (MS). OBJECTIVES: The objective of this paper is to analyse the association of the locus with MS susceptibility and its relationship with intrathecal immunoglobulin (Ig) parameters. METHODS: We genotyped the rs11621145 variant,...
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