Article
Immunological mechanisms that associate with oligoclonal IgM band synthesis in multiple sclerosis.
Clinical immunology (Orlando, Fla.) - 1 Oct 2010
Villar Luisa M, Espiño Mercedes, Cavanillas María L, Roldán Ernesto, Urcelay Elena, de la Concha Emilio G, Sádaba Maria C, Arroyo Rafael, González-Porqué Pedro, Alvarez-Cermeño José C
Abstract excerpt
We described previously that multiple sclerosis (MS) patients with oligoclonal IgM against myelin lipids (M+) develop an aggressive disease. Our aim was to assess possible mechanisms regulating the production of these antibodies. We studied B cell subsets in 180 patients with MS, and 69 with other neurological diseases. M+ MS patients showed a moderate increase of CD5(+) B-cell percentage in peripheral blood and...
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