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Article

Kinetic control by limiting glutaredoxin amounts enables thiol oxidation in the reducing mitochondrial intermembrane space.

Molecular biology of the cell - 15 Jan 2015

Kojer Kerstin, Peleh Valentina, Calabrese Gaetano, Herrmann Johannes M, Riemer Jan

Abstract excerpt

The mitochondrial intermembrane space (IMS) harbors an oxidizing machinery that drives import and folding of small cysteine-containing proteins without targeting signals. The main component of this pathway is the oxidoreductase Mia40, which introduces disulfides into its substrates. We recently showed that the IMS glutathione pool is maintained as reducing as that of the cytosol. It thus remained unclear how...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 25392302
DOI: 10.1091/mbc.E14-10-1422
PMCID: PMC4294668

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Kinetic control by limiting glutaredoxin amounts enables thiol oxidation in the reducing mitochondrial intermembrane space.PMID 25392302Read ↗

In vivo evidence for cooperation of Mia40 and Erv1 in the oxidation of mitochondrial proteins.Semantic proximity Read ↗

Glutaredoxin catalysis requires two distinct glutathione interaction sites.Semantic proximity Read ↗

The redox environment in the mitochondrial intermembrane space is maintained separately from the cytosol and matrix.Semantic proximity Read ↗

Mia40 Protein Serves as an Electron Sink in the Mia40-Erv1 Import Pathway.Semantic proximity Read ↗

Precursor oxidation by Mia40 and Erv1 promotes vectorial transport of proteins into the mitochondrial intermembrane space.Semantic proximity Read ↗

Mitochondrial protein import: Mia40 facilitates Tim22 translocation into the inner membrane of mitochondria.Semantic proximity Read ↗

Unconventional Targeting of a Thiol Peroxidase to the Mitochondrial Intermembrane Space Facilitates Oxidative Protein Folding.Semantic proximity Read ↗

Mia40-dependent oxidation of cysteines in domain I of Ccs1 controls its distribution between mitochondria and the cytosol.Semantic proximity Read ↗

Cytosolic thioredoxin system facilitates the import of mitochondrial small Tim proteins.Semantic proximity Read ↗

Structural and functional roles of the conserved cysteine residues of the redox-regulated import receptor Mia40 in the intermembrane space of mitochondria.Semantic proximity Read ↗

Glutathione is required to regulate the formation of native disulfide bonds within proteins entering the secretory pathway.Semantic proximity Read ↗

Mitochondrial protein import: precursor oxidation in a ternary complex with disulfide carrier and sulfhydryl oxidase.Semantic proximity Read ↗

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