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Article

In vivo evidence for cooperation of Mia40 and Erv1 in the oxidation of mitochondrial proteins.

Molecular biology of the cell - 1 Oct 2012

Böttinger Lena, Gornicka Agnieszka, Czerwik Tomasz, Bragoszewski Piotr, Loniewska-Lwowska Adrianna, Schulze-Specking Agnes, Truscott Kaye N, Guiard Bernard, Milenkovic Dusanka, Chacinska Agnieszka

Abstract excerpt

The intermembrane space of mitochondria accommodates the essential mitochondrial intermembrane space assembly (MIA) machinery that catalyzes oxidative folding of proteins. The disulfide bond formation pathway is based on a relay of reactions involving disulfide transfer from the sulfhydryl oxidase Erv1 to Mia40 and from Mia40 to substrate proteins. However, the substrates of the MIA typically contain two...

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Identifiers

PMID: 22918950
DOI: 10.1091/mbc.E12-05-0358
PMCID: PMC3469512

Genes

MIA

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Related research

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In vivo evidence for cooperation of Mia40 and Erv1 in the oxidation of mitochondrial proteins.PMID 22918950Read ↗

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Kinetic control by limiting glutaredoxin amounts enables thiol oxidation in the reducing mitochondrial intermembrane space.Semantic proximity Read ↗

Structural and functional roles of the conserved cysteine residues of the redox-regulated import receptor Mia40 in the intermembrane space of mitochondria.Semantic proximity Read ↗

Mitochondrial protein import: Mia40 facilitates Tim22 translocation into the inner membrane of mitochondria.Semantic proximity Read ↗

Structural basis of yeast Tim40/Mia40 as an oxidative translocator in the mitochondrial intermembrane space.Semantic proximity Read ↗

Mitochondrial translocation of APE1 relies on the MIA pathway.Semantic proximity Read ↗

Disulfide transfer between two conserved cysteine pairs imparts selectivity to protein oxidation by Ero1.Semantic proximity Read ↗

Novel mitochondrial intermembrane space proteins as substrates of the MIA import pathway.Semantic proximity Read ↗

Mitochondrial Ccs1 contains a structural disulfide bond crucial for the import of this unconventional substrate by the disulfide relay system.Semantic proximity Read ↗

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