Article

The burden of rare protein-truncating genetic variants on human lifespan

2020-06-03

Abstract excerpt

Genetic predisposition is believed to contribute substantially to the age at which we die. Genome-wide association studies (GWAS) have implicated more than 20 genetic loci to phenotypes related to human lifespan 1 . However, little is known about how lifespan is impacted by gene loss-of-function. Through whole-exome sequencing of 238,239 UK Biobank participants, we assessed the relevance of protein-truncating var...

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Literature Corpus work: 6a29d435-0771-56d7-bb2c-3a9c6d98ec6e
DOI: 10.1101/2020.06.02.129908

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