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Article

Deficiency of the stroke relevant HDAC9 gene attenuates atherosclerosis in accord with allele-specific effects at 7p21.1.

Stroke - 1 Jan 2015

Azghandi Sepiede, Prell Caroline, van der Laan Sander W, Schneider Manuela, Malik Rainer, Berer Kerstin, Gerdes Norbert, Pasterkamp Gerard, Weber Christian, Haffner Christof, Dichgans Martin

Abstract excerpt

BACKGROUND AND PURPOSE: Recent genome-wide association studies identified the histone deacetylase 9 (HDAC9) gene region as a major risk locus for large-vessel stroke and coronary artery disease. However, the mechanisms linking variants at this locus to vascular risk are poorly understood. In this study, we investigated the candidacy and directionality of HDAC9 in atherosclerosis and analyzed associations between...

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Share to Apolipoproteins E
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25388417
DOI: 10.1161/STROKEAHA.114.007213

Genes

HDAC9
TWIST1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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