Article
Podoplanin-positive cancer-associated fibroblasts could have prognostic value independent of cancer cell phenotype in stage I lung squamous cell carcinoma: usefulness of combining analysis of both cancer cell phenotype and cancer-associated fibroblast phenotype.
Chest - 1 Apr 2013
Ono Shotaro, Ishii Genichiro, Nagai Kanji, Takuwa Teruhisa, Yoshida Junji, Nishimura Mitsuyo, Hishida Tomoyuki, Aokage Keiju, Fujii Satoshi, Ikeda Norihiko, Ochiai Atsushi
Abstract excerpt
BACKGROUND: The prognostic significance of the tumor microenvironment, which is created by both cancer cells and cancer-associated fibroblasts (CAFs), has been increasingly recognized. The purpose of this study was to analyze the prognostic markers of stage I squamous cell carcinoma (SqCC), with special reference to the immunophenotypes of both cancer cells and CAFs. METHODS: A total of 142 patients with stage I...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.