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Article

RhoA and membrane fluidity mediates the spatially polarized Src/FAK activation in response to shear stress.

Scientific reports - 12 Nov 2014

Liu Bo, Lu Shaoying, Hu Ying-li, Liao Xiaoling, Ouyang Mingxing, Wang Yingxiao

Abstract excerpt

While Src plays crucial roles in shear stress-induced cellular processes, little is known on the spatiotemporal pattern of high shear stress (HSS)-induced Src activation. HSS (65 dyn/cm(2)) was applied on bovine aortic endothelial cells to visualize the dynamic Src activation at subcellular levels utilizing a membrane-targeted Src biosensor (Kras-Src) based on fluorescence resonance energy transfer (FRET). A...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25387906
DOI: 10.1038/srep07008
PMCID: PMC4228346

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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