Article
In search of rare variants: preliminary results from whole genome sequencing of 1,325 individuals with psychophysiological endophenotypes.
Psychophysiology - 1 Dec 2014
Vrieze Scott I, Malone Stephen M, Vaidyanathan Uma, Kwong Alan, Kang Hyun Min, Zhan Xiaowei, Flickinger Matthew, Irons Daniel, Jun Goo, Locke Adam E, Pistis Giorgio, Porcu Eleonora, Levy Shawn, Myers Richard M, Oetting William, McGue Matt, Abecasis Goncalo, Iacono William G
Abstract excerpt
Whole genome sequencing was completed on 1,325 individuals from 602 families, identifying 27 million autosomal variants. Genetic association tests were conducted for those individuals who had been assessed for one or more of 17 endophenotypes (N range = 802-1,185). No significant associations were found. These 27 million variants were then imputed into the full sample of individuals with psychophysiological data...
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