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Article

Hypermethylation can selectively silence individual p16ink4A alleles in neoplasia.

Cancer research - 15 Feb 1998

Myöhänen S K, Baylin S B, Herman J G

Abstract excerpt

Inactivation of p16ink4A and other tumor suppressor genes has been associated with promoter region hypermethylation in neoplasia. However, direct proof for aberrant DNA methylation as an independent event for loss of gene function has been difficult to obtain. We addressed this question in the colon carcinoma cell line HCT116, which contains one allele of p16ink4A with a coding region frameshift mutation and one...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Promoter Regions, Genetic

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Source

Identifiers

PMID: 9485004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Hypermethylation can selectively silence individual p16ink4A alleles in neoplasia.PMID 9485004Read ↗

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