Article
Mutations in trpγ, the homologue of TRPC6 autism candidate gene, causes autism-like behavioral deficits in Drosophila.
Molecular psychiatry - 1 Aug 2022
Palacios-Muñoz Angelina, de Paula Moreira Danielle, Silva Valeria, García Isaac E, Aboitiz Francisco, Zarrei Mehdi, Campos Gabriele, Rennie Olivia, Howe Jennifer L, Anagnostou Evdokia, Ambrozewic Patricia, Scherer Stephen W, Passos-Bueno Maria Rita, Ewer John
Abstract excerpt
Autism Spectrum Disorder (ASD) is characterized by impaired social communication, restricted interests, and repetitive and stereotyped behaviors. The TRPC6 (transient receptor potential channel 6) represents an ASD candidate gene under an oligogenic/multifactorial model based on the initial description and cellular characterization of an individual with ASD bearing a de novo heterozygous mutation disrupting...
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