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Article

Mutant Enrichment with 3'-Modified Oligonucleotides (MEMO)-Quantitative PCR for Detection of NPM1 Mutations in Acute Myeloid Leukemia.

Journal of clinical laboratory analysis - 1 Sept 2015

Shin Sang-Yong, Ki Chang-Seok, Kim Hee-Jin, Kim Jong-Won, Kim Sun-Hee, Lee Seung-Tae

Abstract excerpt

BACKGROUND: Detection of NPM1 mutations in acute myeloid leukemia (AML) is important for risk stratification, treatment decision, and therapeutic monitoring. We have designed a real-time PCR method implementing the Mutant enrichment with 3'-modified oligonucleotides (MEMO) technique to detect NPM1 mutations and validated its utility in clinical samples. METHODS: Sensitivity and linearity were evaluated using...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25384962
DOI: 10.1002/jcla.21779
PMCID: PMC6807112

Genes

NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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