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Article

Detection of minimal residual disease in NPM1-mutated acute myeloid leukemia by next-generation sequencing.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Nov 2014

Salipante Stephen J, Fromm Jonathan R, Shendure Jay, Wood Brent L, Wu David

Abstract excerpt

Detection of minimal residual disease predicts adverse outcome in patients with acute myeloid leukemia. Currently, minimal residual disease may be detected by RQ-PCR or flow cytometry, both of which have practical and diagnostic limitations. Here, we describe a next-generation sequencing assay for minimal residual disease detection in NPM1-mutated acute myeloid leukemia, which encompasses ∼60% of patients with...

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Identifiers

PMID: 24743218
DOI: 10.1038/modpathol.2014.57
PMCID: PMC4201902

Genes

NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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