Article
An allele-specific rt-PCR assay to detect type A mutation of the nucleophosmin-1 gene in acute myeloid leukemia.
The Journal of molecular diagnostics : JMD - 1 May 2008
Ottone Tiziana, Ammatuna Emanuele, Lavorgna Serena, Noguera Nélida I, Buccisano Francesco, Venditti Adriano, Giannì Laura, Postorino Massimiliano, Federici Giorgio, Amadori Sergio, Lo-Coco Francesco
Abstract excerpt
Nucleophosmin-1 (NPM1) mutations represent the most frequent gene alteration in acute myeloid leukemia (AML). The most common NPM1 mutation type, accounting for 75 to 80% of cases, is referred to as mutation A (NPM1-mutA). These NPM1 alterations have been shown to possess prognostic significance because they appear to identify patients who will benefit from chemotherapy. Given the high prevalence and stability of...
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