Article
Quantitative assessment of minimal residual disease in acute myeloid leukemia carrying nucleophosmin (NPM1) gene mutations.
Leukemia - 1 Jun 2006
Gorello P, Cazzaniga G, Alberti F, Dell'Oro M G, Gottardi E, Specchia G, Roti G, Rosati R, Martelli M F, Diverio D, Lo Coco F, Biondi A, Saglio G, Mecucci C, Falini B
Abstract excerpt
Mutations in exon 12 of the nucleophosmin (NPM1) gene occur in about 60% of adult AML with normal karyotype. By exploiting a specific feature of NPM1 mutants, that is insertion at residue 956 or deletion/insertion at residue 960, we developed highly sensitive, real-time quantitative (RQ) polymerase chain reaction (PCR) assays, either in DNA or RNA, that are specific for various NPM1 mutations. In all 13 AML...
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