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Article

NOTCH-induced aldehyde dehydrogenase 1A1 deacetylation promotes breast cancer stem cells.

The Journal of clinical investigation - 1 Dec 2014

Zhao Di, Mo Yan, Li Meng-Tian, Zou Shao-Wu, Cheng Zhou-Li, Sun Yi-Ping, Xiong Yue, Guan Kun-Liang, Lei Qun-Ying

Abstract excerpt

High aldehyde dehydrogenase (ALDH) activity is a marker commonly used to isolate stem cells, particularly breast cancer stem cells (CSCs). Here, we determined that ALDH1A1 activity is inhibited by acetylation of lysine 353 (K353) and that acetyltransferase P300/CBP-associated factor (PCAF) and deacetylase sirtuin 2 (SIRT2) are responsible for regulating the acetylation state of ALDH1A1 K353. Evaluation of breast...

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Source

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Identifiers

PMID: 25384215
DOI: 10.1172/JCI76611
PMCID: PMC4348941

Genes

SIRT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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