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Targeting the DNA damage response in cancer

31 Oct 2024

Abstract excerpt

DNA damage response (DDR) pathway is the coordinated cellular network dealing with the identification, signaling, and repair of DNA damage. It tightly regulates cell cycle progression and promotes DNA repair to minimize DNA damage to daughter cells. Key proteins involved in DDR are frequently mutated/inactivated in human cancers and promote genomic instability, a recognized hallmark of cancer. Besides being an...

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Cancer-related Molecular Pathways
DNA Repair Mechanisms
PARP inhibition in cancer therapy

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39492835
DOI: 10.1002/mco2.788

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