Article
Multiple virulence determinants of foot-and-mouth disease virus in cell culture.
Journal of virology - 1 Aug 1998
Baranowski E, Sevilla N, Verdaguer N, Ruiz-Jarabo C M, Beck E, Domingo E
Abstract excerpt
Hypervirulent variants of foot-and-mouth disease virus (FMDV) of serotype C arise upon serial cytolytic or persistent infections in cell culture. A specific mutation in the internal ribosome entry site of persistent FMDV was previously associated with enhanced translation initiation activity that...
Topics
- Amino Acid Substitution
- Animals
- Aphthovirus
- Binding Sites
- CHO Cells
- Capsid
- Capsid Proteins
- Cell Line
- Cricetinae
- DNA, Complementary
- Genetic Variation
- Genome, Viral
- Heparin
- Models, Molecular
- Mutagenesis, Site-Directed
- Phenotype
- Protein Conformation
- RNA, Viral