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Article

Multiple virulence determinants of foot-and-mouth disease virus in cell culture.

Journal of virology - 1 Aug 1998

Baranowski E, Sevilla N, Verdaguer N, Ruiz-Jarabo C M, Beck E, Domingo E

Abstract excerpt

Hypervirulent variants of foot-and-mouth disease virus (FMDV) of serotype C arise upon serial cytolytic or persistent infections in cell culture. A specific mutation in the internal ribosome entry site of persistent FMDV was previously associated with enhanced translation initiation activity that could contribute to the hypervirulent phenotype for BHK-21 cells. Here we report that several hypervirulent FMDV...

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Identifiers

PMID: 9658076
DOI: 10.1128/JVI.72.8.6362-6372.1998
PMCID: PMC109783

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