Perturbations in the surface structure of A22 Iraq foot-and-mouth disease virus accompanying coupled changes in host cell specificity and antigenicity.

doi:10.1016/s0969-2126(96)00017-2

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Article

Perturbations in the surface structure of A22 Iraq foot-and-mouth disease virus accompanying coupled changes in host cell specificity and antigenicity.

Structure (London, England : 1993) - 15 Feb 1996

Curry S, Fry E, Blakemore W, Abu-Ghazaleh R, Jackson T, King A, Lea S, Newman J, Rowlands D, Stuart D

Abstract excerpt

BACKGROUND: Foot-and-mouth disease virus (FMDV) is an extremely infectious and antigenically diverse picornavirus of cloven-hoofed animals. Strains of the A22 subtype have been reported to change antigenically when adapted to different growth conditions. To investigate the structural basis of thi...

Topics

Antigens, Viral
Aphthovirus
Capsid
Child
Humans
Mutation
Protein Conformation
X-Ray Diffraction

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