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Article

Involvement of protein synthesis in the development of thermotolerance using a CHO temperature-sensitive mutant.

International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group - 1 Jan 2000

Chang P Y, Bjornstad K A, Goncz K, Blakely E A

Abstract excerpt

A Chinese hamster ovary temperature-sensitive mutant (CHO-tsH1) with defective leucyl-tRNA synthetase at temperatures greater than 39 degrees C was used to examine the importance of protein synthesis in the development of thermotolerance. Its wild-type parent CHO-SC1 was used as the control. At temperatures of 41.5 degrees C, 42 degrees C and 42.5 degrees C, SC1 showed the classical biphasic thermotolerant...

Topics

Animals
Cell Line
Cell Survival
Cricetinae
Cricetulus
Female
Heat-Shock Proteins
Hot Temperature
Kinetics
Leucine-tRNA Ligase
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ovary

Source

Identifiers

PMID: 2299224
DOI: 10.3109/02656739009140808

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2299224-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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