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Article

Development of thermotolerance in hsp70 induction-defective mutant of NRK cells.

International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group - 1 Jan 2000

Sakakibara Y, Shimada Y, Masuda A, Ohtsuka K

Abstract excerpt

We investigated the relation between the synthesis of inducible form of heat-shock protein 70 (hsp70) and the development of thermotolerance using NRK (normal rat kidney) cells and their mutant cell line (39-1 cells). In NRK cells, hsp70 was clearly induced by conditioning treatments (42 degrees C for 2 h, 45 degrees C for 15 min or 100 microM sodium arsenite for 1 h). On the other hand, the induction of hsp70 in...

Topics

Animals
Arsenic
Arsenites
Cell Line
Cell Survival
Heat-Shock Proteins
Hot Temperature
Kinetics
Mutation
Protein Biosynthesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 1607738
DOI: 10.3109/02656739209021788

Genes

NRK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1607738-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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