Article
Nucleotide bound to rab11a controls localization in rod cells but not interaction with rhodopsin.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 5 Nov 2014
Reish Nicholas J, Boitet Evan R, Bales Katie L, Gross Alecia K
Abstract excerpt
Precise vectorial transport of rhodopsin is essential for rod photoreceptor health and function. Mutations that truncate or extend the C terminus of rhodopsin disrupt this transport, and lead to retinal degeneration and blindness in human patients and in mouse models. Here we show that such mutat...
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