Article

Disrupting the ciliary gradient of active Arl3 affects rod photoreceptor nuclear migration

2022-05-03

Abstract excerpt

<h4>ABSTRACT</h4> The small GTPase Arl3 is important for the enrichment of lipidated proteins to primary cilia, including the outer segment of photoreceptors. Human mutations in the small GTPase Arl3 cause both autosomal recessive and dominant inherited retinal dystrophies. We discovered that dominant mutations result in increased active G-protein—Arl3-D67V has constitutive activity and Arl3-Y90C is fast cycling—...

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Literature Corpus work: 1a4ed36c-1b5f-5829-813f-d0ee4416d596
DOI: 10.1101/2022.05.02.490367

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