Article
The frequency of mutators in populations of Escherichia coli.
Mutation research - 14 Mar 2000
Boe L, Danielsen M, Knudsen S, Petersen J B, Maymann J, Jensen P R
Abstract excerpt
Owing to occasional spontaneous mutations in genes encoding DNA repair, any population of a reasonable size is expected to harbor a sub-population of genetic mutators. Using a genetically modified strain of Escherichia coli K-12, we have estimated the frequency of mutators to be about 3x10(-5). By and large, this corresponds to a mutation rate from non-mutators to mutators of 5x10(-6) per bacterium per...
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