Article
Mutation accumulation and fitness in mutator subpopulations of Escherichia coli.
Biology letters - 23 Feb 2013
Maharjan Ram P, Liu Bin, Li Yang, Reeves Peter R, Wang Lei, Ferenci Thomas
Abstract excerpt
Bacterial populations in clinical and laboratory settings contain a significant proportion of mutants with elevated mutation rates (mutators). Mutators have a particular advantage when multiple beneficial mutations are needed for fitness, as in antibiotic resistance. Nevertheless, high mutation rates potentially lead to increasing numbers of deleterious mutations and subsequently to the decreased fitness of...
Topics
- Alleles
- DNA Glycosylases
- Escherichia coli
- Escherichia coli Proteins
- Genetic Fitness
- Genome, Bacterial
- Microbial Interactions
- Mutation Rate
- Time Factors