Article
Genomic confirmation of nutrient-dependent mutability of mutators in Escherichia coli.
Genes to cells : devoted to molecular & cellular mechanisms - 1 Dec 2015
Tsuru Saburo, Ishizawa Yuuka, Shibai Atsushi, Takahashi Yusuke, Motooka Daisuke, Nakamura Shota, Yomo Tetsuya
Abstract excerpt
Mutators with increased mutation rates are prevalent in various environments and have important roles in accelerating adaptive evolution. Previous studies on mutator strains of microorganisms have shown that some mutators have constant mutation rates, whereas others exhibit switchable mutation rates depending on nutritional conditions. This suggests that the contributions of mutators on evolution vary with...
Topics
- DNA Polymerase III
- Escherichia coli
- Escherichia coli Proteins
- Gene Deletion
- Genome, Bacterial
- MutS DNA Mismatch-Binding Protein
- Mutation
- Mutation Rate
- Nalidixic Acid
- Sequence Analysis, DNA