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Malformation of Tear Ducts Underlies the Epiphora and Precocious Eyelid Opening inPrickle 1Mutant Mice: Genetic Implications for Tear Duct Genesis

3 Nov 2020

Abstract excerpt

Purpose: Obstruction of the tear drainage causes a range of ocular surface disorders. Hitherto, the genetics of tear duct development and obstruction has been scarcely explored, and related animal models are lacking. This study aims to study the potential role of the Wnt/PCP pathway mediated by Prickle 1 in tear duct development and diseases. Methods: A severe hypomorphic Prickle 1 mutant was generated. Histology...

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PMID: 33141892
DOI: 10.1167/iovs.61.13.6

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