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Article

H-NST induces LEE expression and the formation of attaching and effacing lesions in enterohemorrhagic Escherichia coli.

PloS one - 1 Jan 2014

Levine Jonathan A, Hansen Anne-Marie, Michalski Jane M, Hazen Tracy H, Rasko David A, Kaper James B

Abstract excerpt

BACKGROUND: Enteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli are important causes of morbidity and mortality worldwide. These enteric pathogens contain a type III secretion system (T3SS) responsible for the attaching and effacing (A/E) lesion phenotype. The T3SS is encoded by the locus of enterocyte effacement (LEE) pathogenicity island. The H-NS-mediated repression of LEE expression is counteracted...

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Identifiers

PMID: 24466172
DOI: 10.1371/journal.pone.0086618
PMCID: PMC3897749

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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