Article
Variant base excision repair proteins: contributors to genomic instability.
Seminars in cancer biology - 1 Oct 2010
Nemec Antonia A, Wallace Susan S, Sweasy Joann B
Abstract excerpt
Cells sustain endogenous DNA damage at rates greater than 20,000 DNA lesions per cell per day. These damages occur largely as a result of the inherently unstable nature of DNA and the presence of reactive oxygen species within cells. The base excision repair system removes the majority of DNA lesions resulting from endogenous DNA damage. There are several enzymes that function during base excision repair....
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