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Article

Synthetic DAF-12 modulators with potential use in controlling the nematode life cycle.

The Biochemical journal - 1 Jan 2015

Dansey María V, Alvarez Lautaro D, Samaja Gisela, Escudero Daiana S, Veleiro Adriana S, Pecci Adalí, Castro Olga A, Burton Gerardo

Abstract excerpt

Dafachronic acids (DAs) are 3-keto cholestenoic acids bearing a carboxylic acid moiety at the end of the steroid side chain. These compounds interact with the DAF-12 receptor, a ligand-dependent transcription factor that acts as a molecular switch mediating the choice between arrest at diapause or progression to reproductive development and adult lifespan in different nematodes. Recently, we reported that the...

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PMID: 25374049
DOI: 10.1042/BJ20140833

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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