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Article

Computational and functional characterization of Angiogenin mutations, and correlation with amyotrophic lateral sclerosis.

PloS one - 1 Jan 2014

Padhi Aditya K, Banerjee Kamalika, Gomes James, Banerjee Manidipa

Abstract excerpt

The Angiogenin (ANG) gene is frequently mutated in patients suffering from the neurodegenerative disease--amyotrophic lateral sclerosis (ALS). Most of the ALS-causing mutations in Angiogenin affect either its ribonucleolytic or nuclear translocation activity. Here we report the functional characterization of two previously uncharacterized missense mutations in Angiogenin--D22G and L35P. We predict the nature of...

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Share to Amino Acid Substitution
Share to Amyotrophic Lateral Sclerosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Ribonuclease, Pancreatic

Source

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Identifiers

PMID: 25372031
DOI: 10.1371/journal.pone.0111963
PMCID: PMC4221194

Genes

ANG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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