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Article

Mechanisms of loss of functions of human angiogenin variants implicated in amyotrophic lateral sclerosis.

PloS one - 1 Jan 2012

Padhi Aditya K, Kumar Hirdesh, Vasaikar Suhas V, Jayaram Bhyravabhotla, Gomes James

Abstract excerpt

BACKGROUND: Mutations in the coding region of angiogenin (ANG) gene have been found in patients suffering from Amyotrophic Lateral Sclerosis (ALS). Neurodegeneration results from the loss of angiogenic ability of ANG (protein coded by ANG). In this work, we performed extensive molecular dynamics...

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Identifiers

PMID: 22384259
DOI: 10.1371/journal.pone.0032479
PMCID: PMC3288110

Genes

ANG

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22384259-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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