Article
Characterization of human angiogenin variants implicated in amyotrophic lateral sclerosis.
Biochemistry - 23 Oct 2007
Crabtree Benedict, Thiyagarajan Nethaji, Prior Stephen H, Wilson Peter, Iyer Shalini, Ferns Tyrone, Shapiro Robert, Brew Keith, Subramanian Vasanta, Acharya K Ravi
Abstract excerpt
Human angiogenin (ANG), the first member of the angiogenin family (from the pancreatic ribonuclease A superfamily) to be identified, is an angiogenic factor that induces neovascularization. It has received much attention due to its involvement in the growth of tumors and its elevated expression level in pancreatic and several other cancers. Recently the biological role of ANG has been shown to extend to the...
Topics
- Amyotrophic Lateral Sclerosis
- Cell Line, Tumor
- Cell Proliferation
- Chromatography, High Pressure Liquid
- Circular Dichroism
- Enzyme Stability
- Formazans
- Genetic Variation
- Humans
- Melanoma
- Models, Molecular
- Molecular Weight
- Mutation