Article
Transcriptome-wide association analysis identifies candidate susceptibility genes for prostate-specific antigen levels in men without prostate cancer.
HGG advances - 18 Jul 2024
Chen Dorothy M, Dong Ruocheng, Kachuri Linda, Hoffmann Thomas J, Jiang Yu, Berndt Sonja I, Shelley John P, Schaffer Kerry R, Machiela Mitchell J, Freedman Neal D, Huang Wen-Yi, Li Shengchao A, Lilja Hans, Justice Amy C, Madduri Ravi K, Rodriguez Alex A, Van Den Eeden Stephen K, Chanock Stephen J, Haiman Christopher A, Conti David V, Klein Robert J, Mosley Jonathan D, Witte John S, Graff Rebecca E
Abstract excerpt
Deciphering the genetic basis of prostate-specific antigen (PSA) levels may improve their utility for prostate cancer (PCa) screening. Using genome-wide association study (GWAS) summary statistics from 95,768 PCa-free men, we conducted a transcriptome-wide association study (TWAS) to examine impacts of genetically predicted gene expression on PSA. Analyses identified 41 statistically significant...
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