Article
Structure-function analysis of heterodimer formation, oligomerization, and receptor binding of the Staphylococcus aureus bi-component toxin LukGH.
The Journal of biological chemistry - 2 Jan 2015
Badarau Adriana, Rouha Harald, Malafa Stefan, Logan Derek T, Håkansson Maria, Stulik Lukas, Dolezilkova Ivana, Teubenbacher Astrid, Gross Karin, Maierhofer Barbara, Weber Susanne, Jägerhofer Michaela, Hoffman David, Nagy Eszter
Abstract excerpt
The bi-component leukocidins of Staphylococcus aureus are important virulence factors that lyse human phagocytic cells and contribute to immune evasion. The γ-hemolysins (HlgAB and HlgCB) and Panton-Valentine leukocidin (PVL or LukSF) were shown to assemble from soluble subunits into membrane-bound oligomers on the surface of target cells, creating barrel-like pore structures that lead to cell lysis. LukGH is the...
Topics
- Amino Acid Sequence
- Animals
- Bacterial Proteins
- Binding Sites
- CD11b Antigen
- Crystallography, X-Ray
- HL-60 Cells
- Hemolysin Proteins
- Humans