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Article

Loss of BRMS1 promotes a mesenchymal phenotype through NF-κB-dependent regulation of Twist1.

Molecular and cellular biology - 1 Jan 2015

Liu Yuan, Mayo Marty W, Xiao Aizhen, Hall Emily H, Amin Elianna B, Kadota Kyuichi, Adusumilli Prasad S, Jones David R

Abstract excerpt

Breast cancer metastasis suppressor 1 (BRMS1) is downregulated in non-small cell lung cancer (NSCLC), and its reduction correlates with disease progression. Herein, we investigate the mechanisms through which loss of the BRMS1 gene contributes to epithelial-to-mesenchymal transition (EMT). Using a short hairpin RNA (shRNA) system, we show that loss of BRMS1 promotes basal and transforming growth factor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 25368381
DOI: 10.1128/MCB.00869-14
PMCID: PMC4295387

Genes

BRMS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Loss of BRMS1 promotes a mesenchymal phenotype through NF-κB-dependent regulation of Twist1.PMID 25368381Read ↗

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Direct regulation of TWIST by HIF-1alpha promotes metastasis.Semantic proximity Read ↗

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