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Article

NF-κB regulates mesenchymal transition for the induction of non-small cell lung cancer initiating cells.

PloS one - 1 Jan 2013

Kumar Manish, Allison David F, Baranova Natalya N, Wamsley J Jacob, Katz Adam J, Bekiranov Stefan, Jones David R, Mayo Marty W

Abstract excerpt

The epithelial-to-mesenchymal transition (EMT) is a de-differentiation process that has been implicated in metastasis and the generation of cancer initiating cells (CICs) in solid tumors. To examine EMT in non-small cell lung cancer (NSCLC), we utilized a three dimensional (3D) cell culture syste...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23935876
DOI: 10.1371/journal.pone.0068597
PMCID: PMC3728367

Genes

CIC
SNAI2
TWIST1
ZEB2
KIT
KLF4
MYCN
SNAI1
SOX2
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23935876-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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