Article
Rho and Rho-kinase activity in adipocytes contributes to a vicious cycle in obesity that may involve mechanical stretch.
Science signaling - 25 Jan 2011
Hara Yoshikazu, Wakino Shu, Tanabe Yoshiyuki, Saito Maki, Tokuyama Hirobumi, Washida Naoki, Tatematsu Satoru, Yoshioka Kyoko, Homma Koichiro, Hasegawa Kazuhiro, Minakuchi Hitoshi, Fujimura Keiko, Hosoya Koji, Hayashi Koichi, Nakayama Koichi, Itoh Hiroshi
Abstract excerpt
The development of obesity involves multiple mechanisms. Here, we identify adipocyte signaling through the guanosine triphosphatase Rho and its effector Rho-kinase as one such mechanism. Mice fed a high-fat diet (HFD) showed increased Rho-kinase activity in adipose tissue compared to mice fed a low-fat diet. Treatment with the Rho-kinase inhibitor fasudil attenuated weight gain and insulin resistance in mice on a...
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